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References

References

1. BRAVECTO® Chews [product label]. Madison, NJ: Merck Animal Health; 2019. 2. SENTINEL® SPECTRUM® Chews [product label]. Madison, NJ: Merck Animal Health; 2020. 3. NEXGARD PLUS® [product label]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.; 2023. 4. SIMPARICA TRIO® [product label]. Kalamazoo, MI: Zoetis Inc.; 2020. 5. CREDELIO QUATTRO™ package insert. Greenfield, IN: Elanco Animal Health; 2024. 6. NEXGARD CHEWABLES® [product label]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.; 2019. 7. HEARTGARD® PLUS [product label]. Duluth, GA: Boehringer Ingelheim Animal Health USA Inc.; 2018. 8. CREDELIO® [product label]. Greenfield, IN: Elanco US Inc.; 2020. 9. INTERCEPTOR PLUS® [product label]. Greenfield, IN: Elanco US Inc.; 2020.

Important safety information

Important safety information

BRAVECTO (fluralaner) Chews for Dogs: The most commonly reported adverse reactions include vomiting, lethargy, diarrhea, anorexia and pruritus. In some cases, adverse events have been reported following use in breeding females. BRAVECTO Chews has not been shown to be effective for 12-weeks’ duration in puppies less than 6 months of age. BRAVECTO Chews is not effective against lone star ticks beyond 8 weeks of dosing. Indicated for dogs 6 months of age and older.  BRAVECTO 1-MONTH (fluralaner) Chews: The most commonly reported adverse reactions include itching, diarrhea, vomiting, decreased appetite, elevated ALT, lethargy, and weight loss. Not effective against lone star ticks in puppies less than 6 months of age. Indicated for dogs 8 weeks of age and older. BRAVECTO (fluralaner topical solution) for Dogs:  The most commonly reported adverse reactions include vomiting, hair loss, diarrhea, lethargy, decreased appetite, and moist dermatitis/rash. BRAVECTO Topical Solution for dogs has not been shown to be effective for 12-weeks’ duration in puppies less than 6 months of age. BRAVECTO Topical Solution for Dogs is not effective against lone star ticks beyond 8 weeks of dosing.  For topical use only.  Avoid oral ingestion. Indicated for dogs 6 months of age and older. BRAVECTO QUANTUM (fluralaner for extended-release injectable suspension) for Dogs: The most commonly reported adverse reactions in a US field study included lethargy, decreased appetite, vomiting, diarrhea, elevated liver enzymes and pruritus. BRAVECTO QUANTUM is not effective against lone star ticks beyond 8 months of dosing. Indicated for dogs 6 months of age and older. 

BRAVECTO (fluralaner topical solution) for Cats: The most commonly reported adverse reactions include vomiting, itching, diarrhea, hair loss, decreased appetite, lethargy, and scabs/ulcerated lesions. BRAVECTO Topical Solution for Cats is not effective against American dog ticks beyond 8 weeks of dosing. BRAVECTO Topical Solution for Cats has not been shown to be effective for 12-weeks’ duration in kittens less than 6 months of age. The safety of BRAVECTO Topical Solution for Cats have not been established in breeding, pregnant and lactating cats. For topical use only.  Avoid oral ingestion.  Indicated for cats 6 months of age and older.  BRAVECTO PLUS (fluralaner and moxidectin topical solution) for Cats:  The most commonly reported adverse reactions include vomiting, hair loss, itching, diarrhea, lethargy, dry skin, elevated ALT, and hypersalivation. BRAVECTO PLUS has not been shown to be effective for 2 months in kittens less than 6 months of age.  Use with caution in cats that are heartworm positive.  The effectiveness of BRAVECTO PLUS to prevent heartworm disease after bathing or water immersion has not been evaluated. The safety of BRAVECTO PLUS have not been established in breeding, pregnant and lactating cats. Indicated for cats 6 months of age and older.

All BRAVECTO products contain fluralaner, which is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders. Neurologic adverse reactions have been reported in cats receiving isoxazoline class drugs, even in cats without a history of neurologic disorders. Use with caution in cats with a history of neurologic disorders.

SENTINEL^® SPECTRUM^® Chews (milbemycin oxime/lufenuron/praziquantel). Dogs should be tested for heartworm prior to use. Mild hypersensitivity reactions have been noted in some dogs carrying a high number of circulating microfilariae. Treatment with fewer than 6 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. For complete product information refer to the product insert.

SENTINEL^® FLAVOR TABS^® (milbemycin oxime/lufenuron). Dogs should be tested for heartworm prior to use. In a small percentage of treated dogs, digestive, neurologic, and skin side effects may occur. For complete product information refer to the product insert.